Following oral administration of the immediate-release formulation, the plasma level of felodipine also declined polyexponentially with mean terminal t1 of 11 to 16 hours. PLENDIL generic Plendil is used for treatment of high blood pressure, alone or with other medications. Six metabolites, which account for 23 of the oral dose, have been none has significant chce kupic plendil vasodilating activity. Grapefruit juice-Co-administration of felodipine with grapefruit juice resulted in more than 2-fold increase in the AUC and Cmax, but no prolongation in the half-life of felodipine.