625 mg daily 263 were compared to the effects of conjugated estrogen alone 261 in 1-year, randomized, double-blind study of women ages 37 to 82 years, who were on average 14 years postmenopausal. Physicians must therefore weigh the potential benefits and unknown risks carefully. ACTONEL 35 mg once-a-week produced significant mean increases in BMD at the lumbar spine, femoral neck, trochanter, and total hip compared to placebo after years of treatment treatment difference: lumbar spine,. RxList does not provide medical advice, diagnosis or treatment. Make ostaa actonel postiennakko sure your dentist knows your entire medical history, including any cancer radiation treatments. Patients should be instructed that if they miss dose of ACTONEL 35 mg once week, they should take tablet on the morning after they remember and return to taking tablet once week, as originally scheduled on their chosen day. Decreased implantation was noted in female rats treated with doses mg kg day approximately.