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The degree to which hydrochlorothiazide is removed by hemodialysis has not been established. The oral LD50 of hydrochlorothiazide is greater than 10 kg in the mouse and rat. Mg combination was well tolerated and showed additional BP reduction. The effect is produced by minoxidil sulfate, the active metabolite. When MICROZIDE and non-steroidal anti-inflammatory agents are used concomitantly, the patients should be observed closely to determine if the desired effect of the diuretic is obtained. Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn. Because animal reproduction studies are not always predictive of human response, this drug should canada microzide no prescription be used during pregnancy only if clearly needed.
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